Down Syndrome Developmental Brain Transcriptome Searchable Database

Gene Search

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Enter gene symbols (e.g., FEZF2 ):

Brain structure:


Network Module Search

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The Down Syndrome Developmental Brain Transcriptome database was developed as a part of the HBT (Human Brain Transcriptome) project at the Department of Neurobiology Yale University School of Medicine. This public database provides searchable differential gene expression information of transcriptome data and associated metadata (e.g. WCGNA gene modules) in developing and adult Down Syndrome (DS) versus control human brain. In this project, differential gene expression data were derived from genome-wide, exon-level transcriptome analysis using Affymetrix GeneChip Human Exon 1.0 ST Arrays of samples through pairwise analysis of 15 sets of DS and control brains. Specimens range from embryonic development to adulthood. This tool thereby enables queries of differential expression for genes of interest, as well as 60 modules of highly coregulated genes, over the course of human development. The HBT project is funded by the National Institute of Health (U01MH081896). Analysis of the DS transcriptome was also funded by the National Institute of Health (NS076503 and MH106934). Additional data will be incorporated into the database as it becomes available. For more information, please contact us.


Olmos-Serrano L, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Publication Pending.

Please send questions and comments to Mingfeng Li (Ph.D)